The main purpose of this study was to illustrate the effect of borneol on pharmacokinetics of salvianolic acid B (SalB) in rats after oral administration of SalB with different doses of borneol. The concentrations of SalB in rat plasma were determined by an established and validated
LC-MS/MS method. Our data showed that when 20, 40, and 80 mg kg− 1 of borneol were orally administrated with SalB at 50 mg kg− 1, C
max of SalB was increased by 18.4%, 55.8%, and 103.2% compared with that of
SalB alone. And AUC0 − t
of SalB in plasma was increased by 14.4%, 48.5%, and 123.3%, respectively. The results indicated that borneol is able to enhance the intestinal absorption and relative bioavailability of SalB, with a positive dose-dependent relationship.
The described herb–drug interactions might prove the scientific rationality of the compatible ratio of traditional Chinese medicines.
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salvianolic acid B
Document Type: Research Article
Laboratory of Drug Metabolism and Pharmacokinetics, Shenyang Pharmaceutical University, 103 Wenhua RoadShenyang,110016, China
Tianjin State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, 308 Anshan West RoadTianjin,300193, China
June 1, 2012