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Two new sesquiterpene lactones from the supercritical fluid extract of Centipeda minima

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Two new sesquiterpene lactones, minimolides G (1) and H (2), were isolated from the supercritical fluid extract of Centipeda minima. Their structures were elucidated on the basis of extensive analyses of spectroscopic data including IR, HR-ESI-MS, 1D and 2D NMR. Compounds 1 and 2 displayed inhibitory activity against human nasopharyngeal cancer cell line (CNE) with IC50 values of 61.4 and 28.7 μM, respectively.
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Keywords: Centipeda minima; antiproliferative activity; sesquiterpene lactones; supercritical fluid extract

Document Type: Research Article

Affiliations: 1: Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou,510632, China 2: The Joint Laboratory for Brain Function and Health, Jinan University, Guangzhou,510632, China

Publication date: June 1, 2012

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