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Home / Journal of Asian Natural Products Research, Volume 13, Number 12

Cytotoxic triterpene saponins from Clematis mandshurica

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Authors: He, Yu-Xin 1 ; Li, Ling 1 ; Zhang, Kang 1 ; Liu, Zhong-Rong 2 ; 

Source: Journal of Asian Natural Products Research, Volume 13, Number 12, 1 December 2011, pp. 1104-1109(6)

Publisher: Taylor and Francis Ltd

DOI: https://doi.org/10.1080/10286020.2011.618453

Two new triterpene saponins, mandshunosides A and B (1 and 2), were isolated from the roots and rhizomes of Clematis mandshurica. Their structures were elucidated on the basis of spectroscopic evidence and hydrolysis products. Compounds 1 and 2 showed inhibitory activities against two colorectal human cancer cells HCT 116 (IC50 2.1 μM for 1 and 2.5 μM for 2) and HT-29 (IC50 3.7 μM for 1 and 3.3 μM for 2).

Keywords: Clematis mandshurica; cytotoxicity; mandshunoside A; mandshunoside B; triterpene saponins

Document Type: Research Article

Affiliations: 1: Bioengineering College, Xihua University, ChengduSichuan610039, China 2: Chengduzhihao Pharmaceutical Co., Ltd, The Life Science and Technology Park, Chengdu High Tech Zone, Sichuan610041, China

Publication date: 01 December 2011

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