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Synthesis and antitumor activity of novel podophyllotoxin derivatives against multidrug-resistant cancer cells

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Seven novel 4-N-substituted podophyllotoxin derivatives with indole rings were prepared and evaluated for cytotoxicity against human cancer cell lines HeLa, KB, KBV, K562, and K562/AO2. Most of them demonstrated improved antitumor activity and weak multidrug resistance compared to the drugs currently available.
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Keywords: antitumor; cytotoxicity; indole; podophyllotoxin; prepare

Document Type: Research Article

Affiliations: 1: Key Laboratory of Industrial Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, China 2: Pharmacognosy Division, Medical College of Chinese People's Armed Police Force, Tianjin, China,Graduate School of Tianjin Medical University, Tianjin, China 3: Pharmacognosy Division, Medical College of Chinese People's Armed Police Force, Tianjin, China 4: Tianjin Key Laboratory of Industrial Microbiology, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, China

Publication date: May 1, 2011

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