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Dibenzocyclooctadiene lignans from the fruits of Schisandra rubriflora and their anti-HIV-1 activities

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Two new dibenzocyclooctadiene lignans, rubrilignans A and B (1, 2), together with 17 known ones, were isolated from the fruits of Schisandra rubriflora. The structures of 1 and 2 were elucidated by spectroscopic methods including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were also evaluated for their anti-HIV-1 activities and showed weak anti-HIV-1 activity with EC50 values of 2.26 and 1.82 g/ml, and therapeutic index values of 35.5 and 18.6, respectively.
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Keywords: Schisandra rubriflora; Schisandreae; anti-HIV-1 activity; dibenzocyclooctadiene lignans; fruits

Document Type: Research Article

Affiliations: 1: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China 2: Key Laboratory of Ethnic Medicine Resource Chemistry (Yunnan University of Nationalities), State Ethnic Affairs Commission & Ministry of Education, Kunming, China

Publication date: May 1, 2011

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