Two new amides with cytotoxic activity from the fruits of Piper longum
Bioassay-guided fractionation of the fruits of Piper longum afforded two new minor amides, piperlongimin A (2) [2E-N-isobutyl-hexadecenamide] and piperlongimin B (4) [2E-octadecenoylpiperidine] together with five known compounds with moderate cytotoxic activity. The structures were elucidated on the basis of spectroscopic evidences. All these compounds inhibited cell proliferation of human leukemia, HL-60 cell lines, and displayed major apoptosis-inducing effects.
Keywords: HL-60; Piper longum; alkylamide; cytotoxic; piperlongimin A; piperlongimin B
Document Type: Research Article
Affiliations: 1: Department of Biotechnology, Amity Institute of Biotechnology, Amity University, Noida, India 2: Division of Cancer Pharmacology, Indian Institute of Integrative Medicine, Jammu, India
Publication date: 01 February 2011
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