Macagigantin, a farnesylated flavonol from Macaranga gigantea
A new farnesylated flavonol derivative, macagigantin (1), together with two known flavonoids, glyasperin A (2) and apigenin (3), had been isolated from the acetone extract of the leaves of Macaranga gigantea. The structure of the new compound was elucidated as 6-farnesylkaempferol based on its spectroscopic data, including UV, IR, 1D and 2D NMR, and HR-EI-MS spectra. Compounds 1-3 were evaluated for their cytotoxic properties against P-388 cells, their IC50 values being 11.3, 6.0, and 5.1 M, respectively.
Keywords: Euphorbiaceae; Macaranga gigantea; P-388 cells; cytotoxicity; farnesylated flavonol; macagigantin
Document Type: Research Article
Affiliations: 1: Natural Products Chemistry Research Group, Organic Chemistry Division, Institut Teknologi Bandung, Bandung, Indonesia 2: Indonesian Institute of Science, Research Center for Chemistry, Tangerang, Indonesia
Publication date: 01 November 2009
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