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Terpenoids from the tuber of Cremastra appendiculata

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Two new terpenoids including a cadinane sesquiterpene (1), and an ent-kaurane diterpene diglycoside (2), together with a known triterpene containing 32 carbons (3), have been isolated from the ethanolic extract of Cremastra appendiculata. Their structures were established by the spectroscopic methods including the IR, MS, 1D-, and 2D-NMR experiments as ( - )-cadin-4,10(15)-dien-11-oic acid (1), ( - )-ent-12-hydroxykaur-16-en-19-oic acid, 19-O--d-xylopyranosyl-(1 → 6)-O--d-glucopyranoside (2), and (+)-24,24-dimethyl-25,32-cyclo-5α-lanosta-9(11)-en-3-ol (3). Compounds 1-3 were evaluated against several human cancer cell lines. Compound 3 showed in vitro-selective cytotoxicity against human breast cancer cell lines (MCF-7) with an IC50 of 3.18 M, but 1 and 2 were inactive (IC50>10 g/ml).
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Keywords: Cremastra appendiculata; Orchidaceae; cytotoxic activities; terpenoids

Document Type: Research Article

Affiliations: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

Publication date: July 1, 2008

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