Two novel bibenzyl trigonopols A (1) and B (2), together with seven known compounds, gigantol (3), tristin (4), moscatin (5), hircinol (6), naringenin (7), 3-(4-hydroxy-3-methoxyphenyl)-2-propen-1-ol (8), and ( - )-syringaresinol (9), have been isolated from the stems of Dendrobium trigonopus, of which compounds 6, 8, and 9 were isolated for the first time from this species. The structures of two new compounds were elucidated as threo-22-(17-hydroxyl-9-(3-hydroxyl-4-methoxy-phenethyl)-13,16,18-trimethoxy-21H-benzo[c]chromen-21-yl)ethane-22, 23-diol (1) and 9-(4-hydroxyl-3-methoxy-phenethyl)-17-(21-hydroxyl-20-methoxy-phenyl)chroman-11, 16-diol (2) on the basis of spectroscopic methods. Trigonopol A was found to exhibit antiplatelet aggregation activity in vitro with 67.55% inhibitory ration at 1.4337 × 10- 3 M.
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anti-platelet aggregation activity;
trigonopols A and B
Document Type: Research Article
State Key Laboratory of Phytochemistry and Plant Resource in West China, Kunming Institute of Botany, the Chinese Academy of Science, Kunming, China,Graduate School of the Chinese Academy of Sciences, Beijing, China
State Key Laboratory of Phytochemistry and Plant Resource in West China, Kunming Institute of Botany, the Chinese Academy of Science, Kunming, China
Yunnan University, Kunming, China
July 1, 2008