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Antifungal stilbenoids from Stemona japonica

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Three new dihydrostilbenes, stilbostemins P-R (1-3), and a new dihydrophenanthrene, stemanthrene G (4), were isolated from the roots of Stemona japonica together with three known bibenzyls, 3,5-dihydroxy-2'-methoxy bibenzyl (5), 3,3'-dihydroxy-2,5'-dimethoxy bibenzyl (6), and 3,5,2'-trihydroxy-4-methyl bibenzyl (7). Their structures were elucidated by spectroscopic analyses. Compounds 5 and 6 exhibited strong antifungal activities against Candida albicans.
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Keywords: Stemona japonica; antifungal; stemanthrene G; stilbenoids; stilbostemins P-R

Document Type: Research Article

Affiliations: 1: Anhui Institute for Drug Control, Hefei, China 2: Department of TCM Pharmaceutics, Shanghai University of Traditional Chinese Medicine, Shanghai, China

Publication date: July 1, 2008

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