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Cytotoxic sesquiterpenoids from Vernonia bockiana

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Two new sesquiterpenoids, vernobockolides A (1) and B (2), along with five known ones, piptocarphin C (3), piptocarphin F (4), piptocarphin A (5), hirsutolide (6), and -d-glucopyranosyl taraxinic ester (7), were isolated from the aerial part of Vernonia bockiana. Their structures were determined by spectroscopic analysis, especially 2D NMR. Among them, compounds 2-6 showed strong cytotoxic activities against mouse lymphoid tumor cell line P388 with the IC50 values of 1.81, 1.32, 0.77, and 0.73 M, respectively.
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Keywords: Compositae; Vernonia bockiana; cytotoxic activity; sesquiterpenoid; vernobockolides A and B

Document Type: Research Article

Affiliations: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

Publication date: June 1, 2008

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