New α-pyrrolidinonoids and glycosides from Euphorbia humifusa
A phytochemical investigation on the constituents from Euphorbia humifusa Willd. has resulted in the isolation of three new α-pyrrolidinonoidal compounds, 5-methoxy-4-hydroxy-3-methylene-α-pyrrolidinone (1), 5-methoxy-4α-hydroxy-3-methylene-α-pyrrolidinone (2), and 5-butoxy-4α-hydroxy-3-methylene-α-pyrrolidinone (3), and three new glycosides including an indole glycoside, 3-(2-hydroxyethyl)-5-(1-O--glucopyranosyloxy)-indole (4), an ionone glycoside, 3-oxo-7,8-dihydro-α-ionone-11-O--glucoside (5), and a hemiterpene glycoside, 1-(4-hydroxy-2-methyl-2-buten-1-yl)-6- (3,4,5-trihydroxybenzoyl)--d-glucose (6), along with 10 known compounds. Their structures were elucidated by analysis of 1D and 2D NMR spectral data. The structure of 1 was further confirmed by a single-crystal X-ray diffraction analysis.
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Document Type: Research Article
Affiliations: Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
Publication date: June 1, 2008