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Two new steroidal compounds from starfish Asterias amurensis Lutken

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Two new sulfated steroidal compounds (1 and 2), along with three known steroidal saponins (3, 4, and 5) were isolated from the starfish Asterias amurensis Lutken. The structures of new compounds were elucidated as 3-O-sulfated-cholest-5-ene-7α-ol (1) and (E) 25-O--d-xylopyranosyl-26, 27-dinor-24(S)-methyl-22-ene-15α-O-sulfated-5α-cholest-3,6α-ol (2) by extensive NMR experiments and chemical evidence. Their effects on UMR106 cell proliferation were screened by MTT method. The results indicated that compounds 2 and 2a (0.01-100 M) significantly promoted the osteoblastic proliferation. The initial structure-activity relationship analysis suggests that the sugar moiety is the necessary group for the activity.
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Keywords: Asteria amurensis; UMR106 cell proliferation; starfish; steroid

Document Type: Research Article

Affiliations: 1: School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing, China 2: School of Pharmaceutical Sciences, Shanxi Medical University, Taiyuan, China 3: Department of Natural Product Chemistry, Shenyang Pharmaceutical University, Shenyang, China 4: College of Chemistry & Enviromental Science, Hebei University, Baoding, China 5: Life Science Division, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China

Publication date: June 1, 2008

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