Two new steroidal compounds from starfish Asterias amurensis Lutken
Two new sulfated steroidal compounds (1 and 2), along with three known steroidal saponins (3, 4, and 5) were isolated from the starfish Asterias amurensis Lutken. The structures of new compounds were elucidated as 3-O-sulfated-cholest-5-ene-7α-ol (1) and (E) 25-O--d-xylopyranosyl-26, 27-dinor-24(S)-methyl-22-ene-15α-O-sulfated-5α-cholest-3,6α-ol (2) by extensive NMR experiments and chemical evidence. Their effects on UMR106 cell proliferation were screened by MTT method. The results indicated that compounds 2 and 2a (0.01-100 M) significantly promoted the osteoblastic proliferation. The initial structure-activity relationship analysis suggests that the sugar moiety is the necessary group for the activity.
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UMR106 cell proliferation;
Document Type: Research Article
School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing, China
School of Pharmaceutical Sciences, Shanxi Medical University, Taiyuan, China
Department of Natural Product Chemistry, Shenyang Pharmaceutical University, Shenyang, China
College of Chemistry & Enviromental Science, Hebei University, Baoding, China
Life Science Division, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China
Publication date: June 1, 2008