Skip to main content
padlock icon - secure page this page is secure

Neuroprotection of ginsenoside Re in cerebral ischemia-reperfusion injury in rats

Buy Article:

$61.00 + tax (Refund Policy)

In the present study, we have investigated the neuroprotective potential of ginsenoside Re (Re) in the middle cerebral artery occlusion model in Sprague-Dawley rats. Adult male Sprague-Dawley rats were treated with Re (5, 10 or 20 mg kg- 1, P.O. for 7 days, once a day) prior to occlusion. There was a significant increase in the neurological symptoms in ischemic animals as compared with the sham group animals. These effects were attenuated by 10 and 20 mg kg- 1 Re, P.O. There was a significant increase in the level of malondialdehyde (MDA) in ischemic animals indicating oxidative stress. An elevated level of MDA in ischemic animals was reduced by 10 and 20 mg kg- 1 Re, P.O., respectively. It was observed that Re significantly decreased mitochondrial swelling, thereby preventing the reduction of H+-ATPase activity. This study demonstrates the neuroprotective potential of Re in cerebral ischemia-reperfusion injury in rats.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics

Keywords: H+-ATPase; cerebral ischemia; ginsenoside Re; mitochondrial swelling; reperfusion injury

Document Type: Research Article

Affiliations: 1: Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, China 2: Institute of Physical Organic and Medicinal Chemistry, Capital Normal University, Beijing, China

Publication date: May 1, 2008

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more