A new elemanolide sesquiterpene lactone, named elescaberin (1), together with two known compounds, namely, isodeoxyelephantopin (2) and deoxyelephantopin (3), was isolated from the whole plant of Elephantopus scaber. The structure of 1 was elucidated on the basis of spectroscopic analysis. All three compounds exhibited significant inhibitory activities against human SMMC-7721 liver cancer cells in vitro (IC50 8.18-14.08 mol/l).
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Document Type: Research Article
Department of Medicinal Chemistry, Nanjing University of Chinese Medicine, Nanjing, China
Department of Natural Medicine Chemistry, China Pharmaceutical University, Nanjing, China
Jiangsu Key Laboratory for TCM Formulae Research, Nanjing University of Chinese Medicine, Nanjing, China
May 1, 2008