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Home / Journal of Asian Natural Products Research, Volume 10, Number 5

A new elemanolide sesquiterpene lactone from Elephantopus scaber

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Authors: Liang, Qiao-Li 1 ; Min, Zhi-Da 2 ; Tang, Yu-Ping 3 ; 

Source: Journal of Asian Natural Products Research, Volume 10, Number 5, 1 May 2008, pp. 403-407(5)

Publisher: Taylor and Francis Ltd

DOI: https://doi.org/10.1080/10286020801966526

A new elemanolide sesquiterpene lactone, named elescaberin (1), together with two known compounds, namely, isodeoxyelephantopin (2) and deoxyelephantopin (3), was isolated from the whole plant of Elephantopus scaber. The structure of 1 was elucidated on the basis of spectroscopic analysis. All three compounds exhibited significant inhibitory activities against human SMMC-7721 liver cancer cells in vitro (IC50 8.18-14.08 mol/l).

Keywords: Compositae; Elephantopus scaber; anticancer; elescaberin; sesquiterpene lactone

Document Type: Research Article

Affiliations: 1: Department of Medicinal Chemistry, Nanjing University of Chinese Medicine, Nanjing, China 2: Department of Natural Medicine Chemistry, China Pharmaceutical University, Nanjing, China 3: Jiangsu Key Laboratory for TCM Formulae Research, Nanjing University of Chinese Medicine, Nanjing, China

Publication date: 01 May 2008

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