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A new elemanolide sesquiterpene lactone from Elephantopus scaber

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A new elemanolide sesquiterpene lactone, named elescaberin (1), together with two known compounds, namely, isodeoxyelephantopin (2) and deoxyelephantopin (3), was isolated from the whole plant of Elephantopus scaber. The structure of 1 was elucidated on the basis of spectroscopic analysis. All three compounds exhibited significant inhibitory activities against human SMMC-7721 liver cancer cells in vitro (IC50 8.18-14.08 mol/l).
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Keywords: Compositae; Elephantopus scaber; anticancer; elescaberin; sesquiterpene lactone

Document Type: Research Article

Affiliations: 1: Department of Medicinal Chemistry, Nanjing University of Chinese Medicine, Nanjing, China 2: Department of Natural Medicine Chemistry, China Pharmaceutical University, Nanjing, China 3: Jiangsu Key Laboratory for TCM Formulae Research, Nanjing University of Chinese Medicine, Nanjing, China

Publication date: May 1, 2008

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