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Cytotoxic sesquiterpene lactones from Eupatorium lindleyanum

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Three new germacrane sesquiterpenes, eupalinolides C-E (1-3), along with three known germacrane sesquiterpenes, eupalinolide A (4), eupalinolide B (5), and 3-acetoxy-8-(4'-hydroxytigloyloxy)-14-hydroxycostunolide (6), were isolated from Eupatorium lindleyanum. They were tested for cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines. The results showed that these compounds demonstrated potent cytotoxicity. The structures of the compounds were elucidated by means of 1H and 13C NMR spectroscopic analysis, including 2D NMR experiments.
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Keywords: Compositae; Eupalinolide C; Eupalinolide D; Eupalinolide E; Eupatorium lindleyanum; Sesquiterpene

Document Type: Research Article

Affiliations: 1: Department of Pharmacognosy, China Pharmaceutical University, Nanjing, China,Department of Phytochemistry, Jiangsu Academy of Traditional Chinese Medicine, Nanjing, China 2: Department of Phytochemistry, Jiangsu Academy of Traditional Chinese Medicine, Nanjing, China 3: Department of Pharmacognosy, China Pharmaceutical University, Nanjing, China 4: Technology Center, Jinling Pharmaceutical Company Limited, Nanjing, China

Publication date: January 1, 2007

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