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Home / Journal of Asian Natural Products Research, Volume 9, Number 3

Two forms of long-term potentiation induced by different compounds

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The purpose of this study was to investigate different forms of long-term potentiation (LTP) induced by different compounds. As shown in results, the influx of calcium via voltage-dependent calcium channels (VDCCs) was responsible for ( - )-clausenamide-induced LTP in hippocampus, while Rg1 induced LTP is mediated by the entry of calcium via N-methyl-d-aspartate glutamate (NMDA) receptor. The findings in the present study provide pharmacological basis for the nootropic mechanisms of these two compounds.

Keywords: Clausenamide; Long-term potentiation; N-methyl-d-aspartate glutamate receptor (NMDAR); Rg1; Voltage-dependent calcium channels (VDCCs)

Document Type: Research Article

Affiliations: Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

Publication date: 01 April 2007

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