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Biotransformation of triptolide and triptonide by cell suspension cultures of Catharanthus Roseus

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Catharanthus roseus cell suspension cultures were used to bioconvert both triptolide (1) and triptonide (2). The same reaction path was followed in both biotransformations. Two biotransformed products were obtained and their structures identified as triptriolide (3) and 12β,13α-dihydroxytriptonide (4), respectively, from 1 and 2. Product 4 is a new compound.
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Keywords: Biotransformation; Cell suspension cultures; Triptolide; Triptonide

Document Type: Research Article

Affiliations: 1: Shenyang Pharmaceutical University Shenyang 110016 Liaoning China 2: The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences Peking University 100083 Beijing China 3: Center for Drug Evaluation of State Drug Administration 100038 Beijing China

Publication date: June 1, 2004

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