Catharanthus roseus cell suspension cultures were used to bioconvert both triptolide (1) and triptonide (2). The same reaction path was followed in both biotransformations. Two biotransformed products were obtained and their structures identified as triptriolide (3) and 12β,13α-dihydroxytriptonide (4), respectively, from 1 and 2. Product 4 is a new compound.
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Cell suspension cultures;
Document Type: Research Article
Shenyang Pharmaceutical University Shenyang 110016 Liaoning China
The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences Peking University 100083 Beijing China
Center for Drug Evaluation of State Drug Administration 100038 Beijing China
Publication date: June 1, 2004