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Effects of alpinetin on rat vascular smooth muscle cells

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The object of this work was to study the effects of alpinetin on cultured rat aortic smooth muscle cells. It was observed that H
2
O
2
(100 μmol L
-1
) induced increase of LDH (lactate dehydrogenase) leakage in the medium of VSMC by 7.4% (p<0.01) and 10
-7
mol L
-1
alpinetin significantly decreased LDH leakage induced by H
2
O
2
(p<0.01). Alpinetin had the effects of inhibiting VSMC proliferation in a dose-dependent manner under the condition of serum stimulation for 24 and 48 h, but with serum stimulation for 72 h adverse effects on VSMC proliferation appeared. 10
-7
and 10
-8
mol L
-1
alpinetin had significantly inhibitory effects on VSMC migration by 67.9% (p<0.001) and 34.1% (p<0.01) respectively. It was also found that alpinetin (10
-7
-10
-9
mol L
-1
) could significantly inhibit the production of NO in cultured VSMC induced by TNFα (200 U ml
-1
). At 10
-7
, 10
-8
and 10
-9
mol L
-1
the modulation of NO was by 22.6% (p<0.001), 20.6% (p<0.01) and 13.9% (p<0.05), respectively. In summary, the data show that alpinetin has, to some extent, protective effects on VSMC.
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Keywords: Alpinetin; Vascular injury; Vascular smooth muscle cells (VSMC)

Document Type: Research Article

Publication date: June 1, 2004

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