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Practical statistical considerations for investigating anti-tumor treatments in mice

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Anti-tumor treatment outcomes in mouse experiments can be challenging to interpret and communicate accurately. In reporting these experiments, rigorous statistical considerations are commonly absent, although statistical applications have been proposed. We investigated the practicality and utility of different statistical strategies for the analysis of anti-tumor responses in a longitudinal mouse case study. Each analysis that we performed had different endpoints, investigated different questions, and was based on different assumptions. We found rudimentary visual and risk analysis insufficient without additional considerations, and upon further investigation we found improvements in key anti-tumor parameter estimates associated with a drug combination in our case study. We offer practical statistical considerations for investigating anti-cancer treatments in mice, applying a multi-tier statistical approach.
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Keywords: Mouse; cancer; inference; nonlinear; tumor

Document Type: Research Article

Affiliations: Bristol-Myers Squibb, Lawrence Township, NJ, USA

Publication date: January 25, 2019

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