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Partial logistic relevance vector machines in survival analysis

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The use of relevance vector machines to flexibly model hazard rate functions is explored. This technique is adapted to survival analysis problems through the partial logistic approach. The method exploits the Bayesian automatic relevance determination procedure to obtain sparse solutions and it incorporates the flexibility of kernel-based models. Example results are presented on literature data from a head-and-neck cancer survival study using Gaussian and spline kernels. Sensitivity analysis is conducted to assess the influence of hyperprior distribution parameters. The proposed method is then contrasted with other flexible hazard regression methods, in particular the HARE model proposed by Kooperberg et al. [16]. A simulation study is conducted to carry out the comparison. The model developed in this paper exhibited good performance in the prediction of hazard rate. The application of this sparse Bayesian technique to a real cancer data set demonstrated that the proposed method can potentially reveal characteristics of the hazards, associated with the dynamics of the studied diseases, which may be missed by existing modeling approaches based on different perspectives on the bias vs. variance balance.
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Keywords: Bayesian methods; automatic relevance determination; hazard regression; kernel methods; relevance vector machines; survival analysis

Document Type: Research Article

Affiliations: 1: Department of Medicine and Public Health,Second University of Naples, Via Luciano Armanni 580138Naples, Italy 2: Institute of Medical Statistics and Biometry,University of Milan, Via Vanzetti 5, Cascina Rosa20133Milan, Italy

Publication date: November 1, 2011

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