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Influence of physical exercise and gender on acetylcholinesterase and butyrylcholinesterase activity in human blood samples

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The determination of cholinesterase activity in plasma and erythrocytes serves as a useful and sensitive biomarker of exposure to organophosphorus and carbamate pesticides. However, acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activity may be influenced by factors such as age, gender, drugs, and physical exercise. The aim of this study was to evaluate the effects of gender and physical exercise on the activity of AChE and BuChE in healthy individuals. The values for both enzymes were lower for women. Physical exercise increased the levels of BuChE, and had no significant effect on AChE. To our knowledge, this is the first clinical study evaluating the influence of physical exercise in levels of these enzymes. Considering that cholinesterase activity is a useful parameter in assessing the exposure of individuals to pesticides, it is important to understand factors that influence the determination of the enzymes in order to avoid the erroneous interpretation of results.
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Keywords: acetylcholinesterase; butyrylcholinesterase; gender-related differences; physical exercise

Document Type: Research Article

Affiliations: 1: Faculdade de Farmácia,Instituto de Toxicologia, Pontíficia Universidade Católica do Rio Grande do Sul, Av Ipiranga 6681, Prédio 12 D, Porto Alegre 90630-180, Rio Grande do Sul, Brazil 2: Curso de Farmácia,Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Pelotas, CEP 96010-900, Rio Grande do Sul, Brazil

Publication date: June 1, 2012

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