Immune-enhancing effects of Portulaca oleracea L.– based complex extract in cyclophosphamide-induced splenocytes and immunosuppressed rats
Portulaca oleracea L. is a traditional oriental medicine known for its pharmacological effects. The present study aimed to investigate the immunostimulatory effects of PPCE on cyclophosphamide-stimulated rat model and in isolated spleen cells. The result showed that PPCE
exerted an immunostimulatory effect in vivo and in vitro. Specifically, PPCE significantly enhanced splenocyte proliferation and upregulated inflammatory cytokines (IL-2, IL-12, TNF-α, and IFN-γ) and NK cell activity in vitro. The immunostimulatory effect was
further investigated through various immunological assays. Oral administration of PPCE increased the swimming time and number of immune cells in rats. Histological analysis revealed that PPCE administration exerted splenic recovery. Thus, P. oleracea L. based complex extracts
may be used as an immunostimulatory agent in medicine or functional foods.
Keywords: Portulaca oleracea L; cytokine; immunostimulation; immunosuppressed rats; spleonocyte
Document Type: Research Article
Affiliations: 1: INVIVO Co. Ltd., Iksan, South Korea 2: Huvet Co. Ltd., Iksan, South Korea 3: MnFkorea, Ltd., Sancheong, South Korea 4: Center for Animal Resources Development, Wonkwang University, Iksan, South Korea 5: Korea Food Research Institute, Wanju-gun, Republic of Korea 6: Department of Oral Biochemistry, and Institute of Biomaterial-Implant, College of Dentistry, Wonkwang University, Iksan, South Korea
Publication date: 01 January 2019
- Editorial Board
- Information for Authors
- Subscribe to this Title
- Ingenta Connect is not responsible for the content or availability of external websites
- Access Key
- Free content
- Partial Free content
- New content
- Open access content
- Partial Open access content
- Subscribed content
- Partial Subscribed content
- Free trial content