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Anti-inflammatory effect of Algerian date fruit (Phoenix dactylifera)

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From ages, dates are consumed by humans for its beneficial health and nutritional values. The aim of this study was to evaluate anti-inflammatory effect of Algerian date fruit (Phoenix dactylifera). A quantity of 50 mg/kg of the P. dactylifera extract was analyzed in vivo using the formalin-induced paw edema test in mice. The inflammation level was detected by the measure of the edema size, also the dosage of C-reactive protein (CRP) and homocysteine levels in the blood. The results showed a highly significant decrease in the edema size and the level of the homocysteine in the blood (P = .000) and significant decrease in CRP values (P < 0.05) in the 50 mg/kg plant extract group compared to Control, Methionine 400 mg/kg and (Plant + Methionine) groups. The study suggests that the extract possesses enough potential to reduce inflammation by in vivo and directs the importance of further research and development of novel anti-inflammatory agents.
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Keywords: Anti-inflammatory; CRP; Phoenix dactylifera; formalin; homocysteine; paw edema

Document Type: Research Article

Affiliations: 1: Laboratoire d’obtention de substances thérapeutiques (Lost), Department of Animal Biology, Université des frères Mentouri-Constantine, Constantine, Algeria 2: Laboratoired’obtention de substances thérapeutiques (Lost), Department of Chemistry, Université des frères Mentouri-Constantine, Constantine, Algeria

Publication date: November 1, 2016

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