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Cytotoxic and genotoxic effects of extracts from Annona montana M. fruit

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Pulverized immature fruits of Annona montana M. are commonly used for biomedical applications, especially in the treatment of dysentery. The aim of this study was to investigate whether hexane, ethyl acetate or methanol extracts of A. montana M. can be cytotoxic to human tumor cells or exhibit genotoxic effects on normal human cells. The organic extracts were shown to inhibit survival of tumor cells originating from human astrocytoma, breast, colon, lung and prostate cancers. Furthermore, they were found to induce DNA damage in normal human lymphocytes, as shown by comet assay. The genotoxic effects observed suggest that traditional folk medicines prepared from extracts of the immature fruit of A. montana should be used with caution.
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Keywords: Annona montana M; comet assay; cytotoxicity; genotoxicity

Document Type: Research Article

Affiliations: 1: Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Circuito Exterior, Coyoacán, Mexico 2: Departamento de Química, Universidad Técnica Particular de Loja, San Cayetano s/n, AP 1101608, Loja, Ecuador 3: Departamento de Ciencias de la Salud, Universidad Técnica Particular de Loja, San Cayetano s/n, CP 1101608, Loja, Ecuador

Publication date: July 3, 2016

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