@article {Usuda:2016:0954-0105:523,
title = "Sasa veitchii extracts suppress 2,4-dinitrofluorobenzene-induced contact hypersensitivity in mice",
journal = "Food and Agricultural Immunology",
parent_itemid = "infobike://tandf/cfai",
publishercode ="tandf",
year = "2016",
volume = "27",
number = "4",
publication date ="2016-07-03T00:00:00",
pages = "523-534",
itemtype = "ARTICLE",
issn = "0954-0105",
eissn = "1465-3443",
url = "https://www.ingentaconnect.com/content/tandf/cfai/2016/00000027/00000004/art00008",
doi = "doi:10.1080/09540105.2015.1129597",
keyword = "T cells, IFN-γ, 2,4-dinitrofluorobenzene, Allergic skin inflammation, Sasa veitchii",
author = "Usuda, Haruki and Fujii, Hirohisa and Nonogaki, Tunemasa",
abstract = "We examined the therapeutic effect of the extract from Sasa veitchii leaves (Sasa extract: SE) on the allergic skin inflammation model. SE derived from 0.141 g (low dose) or 0.562 g (high dose) of the leaves was administered orally for 15 days. High dose of SE suppressed ear
swelling response induced by repeated 2,4-dinitrofluorobenzene (DNFB) paintings, and both low and high doses of SE reduced infiltration of immune cells into the ear dermis. Although the number of T cells, Treg, CD4+T cells and CD8+T cells in draining lymph nodes (dLNs)
was not changed by SE, IFN- secretion from dLN induced by concanavalin A or 2,4-dinitrobenzenesulfonic acid was suppressed by a high dose of SE while IL-10 levels remained unchanged. These results suggest that SE suppresses allergic skin inflammation via reducing IFN- secreted
from immune cells, especially T cells.",
}