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EMSA Eritin polyherbal can suppress NF-κB activation and decrease IL-17 cytokine in an irradiated mice model

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EMSA Eritin which consists of red rice, soybean, and coconut water extract has been widely reported as having antioxidant activity. This study aimed to analyse the effect of EMSA Eritin on nuclear factor (NF)-κB activation and pro-inflammatory cytokines IL-17 after radiation exposure. The experiments were carried out in the irradiated mouse model (6 Gy). Oral administration of EMSA Eritin 1.04, 3.125, and 9.375 mg/g BW for 14 days was compared with injections of 4.16 mg Erythropoietin-αTM (EPO). This study shows an increase in NF-κB activation and IL-17 production in irradiated mice compared to normal mice (p ≤ .05). EPO injection could not prevent these changes. Oral administration of EMSA Eritin suppressed NF-κB activation, and also decreased production of pro-inflammatory IL-17 significantly (p ≤ .05) compared with irradiated mice and irradiated mice treated with EPO.
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Keywords: EMSA Eritin; IL-17; NF-κB; inflammation; radiation

Document Type: Research Article

Affiliations: 1: Biology Department, Brawijaya University, Malang, Indonesia 2: Biomedical Sciences Department, Brawijaya University, Malang, Indonesia

Publication date: May 3, 2016

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