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Effect of Argania spinosa oil extract on proliferation and Notch1 and ERK1/2 signaling of T-cell acute lymphoblastic leukemia cell lines

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The Argan tree, called Argania spinosa (L.) Skeels, is a tropical plant, which belongs to the Sapotaceae family, it is exploited essentially for its fruits. The endosperm seed of the fruit constitutes a good potential source of edible oil for human consumption and is endowed with important medicinal properties such as antioxidant, antimalarial and anti-proliferative. The aim of the present work is to evaluate the anti-proliferative effect of the oil extracted from seeds of A. spinosa in T-cell acute lymphoblastic leukemia human (T-ALL) context. The activity was assessed through an in vitro test on three T-ALL cell lines: JURKAT, MOLT3 and DND41. The cytotoxicity effects of A. spinosa oil extract were checked by MTT assay and the change in the activity levels of two T-ALL proliferation-related proteins (Notch1 and ERK) was investigated by Western blot, the results demonstrate that treatment with A. spinosa oil extract at the dose of 100 μg/mL inhibited the growth of JURKAT, MOLT3 and DND41 cells, and reduced the expression levels and the activity of proliferation-related proteins such as ERK1/2 and Notch1 intracellular domain. A. spinosa oil extract could be a potential preventive and therapeutic approach recommended as anti-proliferative against leukemia.
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Keywords: Argania spinosa oil extract; ERK1/2; Notch1; anti-proliferative effect; leukemia cell lines

Document Type: Research Article

Affiliations: 1: Department of Animal Biology, University of Mentouri Constantine, Constantine, Algeria 2: Department of Chemistry Laboratoire d'Obtention de Substances Thérapeutiques (LOST), University of Mentouri Constantine, Constantine, Algeria 3: Department of Molecular Medicine, Sapienza University, Rome, Italy 4: Center for Life Nano [email protected], Istituto Italiano di Tecnologia, Rome, Italy

Publication date: May 3, 2016

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