The Argan tree, called Argania spinosa (L.) Skeels, is a tropical plant, which belongs to the Sapotaceae family, it is exploited essentially for its fruits. The endosperm seed of the fruit constitutes a good potential source of edible oil for human consumption and is endowed
with important medicinal properties such as antioxidant, antimalarial and anti-proliferative. The aim of the present work is to evaluate the anti-proliferative effect of the oil extracted from seeds of A. spinosa in T-cell acute lymphoblastic leukemia human (T-ALL) context. The activity
was assessed through an in vitro test on three T-ALL cell lines: JURKAT, MOLT3 and DND41. The cytotoxicity effects of A. spinosa oil extract were checked by MTT assay and the change in the activity levels of two T-ALL proliferation-related proteins (Notch1 and ERK) was investigated
by Western blot, the results demonstrate that treatment with A. spinosa oil extract at the dose of 100 μg/mL inhibited the growth of JURKAT, MOLT3 and DND41 cells, and reduced the expression levels and the activity of proliferation-related proteins such as ERK1/2 and Notch1
intracellular domain. A. spinosa oil extract could be a potential preventive and therapeutic approach recommended as anti-proliferative against leukemia.
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Argania spinosa oil extract;
leukemia cell lines
Document Type: Research Article
Department of Animal Biology, University of Mentouri Constantine, Constantine, Algeria
Department of Chemistry Laboratoire d'Obtention de Substances Thérapeutiques (LOST), University of Mentouri Constantine, Constantine, Algeria
Department of Molecular Medicine, Sapienza University, Rome, Italy
Center for Life Nano [email protected], Istituto Italiano di Tecnologia, Rome, Italy
May 3, 2016
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