Eupatorium makinoi suppresses toll-like receptor signaling pathways
Toll-like receptors (TLRs) recognize microbial molecules that are widely presented by pathogens and initiate the innate immune system. TLR signaling is divided into two different signaling pathways, the myeloid differential factor 88 (MyD88)- and Toll/interleukin-1 receptor domain-containing
adapter inducing interferon-β (TRIF)-dependent pathways. Eupatorium makinoi, a plant species in Asteraceae, is used for medicinal purposes in China, Korea, and Japan. Through our previous research, we found that an ethanol extract of E. makinoi (EEM) suppresses
inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression. In this study, we investigated the effect of EEM on TLRs signaling pathways. EEM suppresses NF-κB activation and iNOS and COX-2 expressions induced by TLR2 or TLR4 agonists. Also, EEM suppresses the
activation of interferon (IFNs) regulatory factor 3 (IRF3) induced by TLR3 or TLR4 agonists. All results indicate that EEM suppresses myeloid differentiation primary-response protein 88 (MyD88) and TRIF-dependent signaling pathways of TLRs and the expressions of target genes derived from the
activation of TLRs
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Document Type: Research Article
Departments of Medical Science, College of Medical Sciences, SoonChunHyang University, Chungnam, Asan, 336-745, Republic of Korea
Department of Biomedical Laboratory Science, College of Medical Sciences, SoonChunHyang University, Chungnam, Asan, 336-745, Republic of Korea
Department of Food Science and Nutrition, Hallym University, Chuncheon, Gangwon-do, 200-702, Republic of Korea
Department of Biological Environment, Kangwon National University, Chuncheon, Gangwon-do, 200-701, Republic of Korea
March 3, 2016
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