Dinitramine is a herbicide that has been used to control annual grasses and broadleaf weeds in cotton and soybeans in Iran. In this study, the electrochemical behavior of dinitramine was studied by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) methods. The interaction
of dinitramine with ct-DNA was evaluated by CV, competitive fluorescence, UV-Vis spectroscopy, FT-IR spectroscopy, and viscosity titration. In addition, the thermodynamic parameters of DIN–DNA complex were calculated by spectrophotometric titration. The values of ΔHbin.,
ΔSbin., and ΔGbin. (T = 290.65 K) of the DIN–DNA complex were +39.25 kJ mol−1, +215.71 J mol−1, and −23.45 KJ mol−1, respectively. These data revealed that the endothermic binding has its origin
in the hydrophobic interactions. Also the high positive ΔSbin was explained according to the DIN structure that optimized by mechanical quantum calculations. However, all data showed that the major groove binding between DIN and ct-DNA is more predominant than other binding
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Document Type: Research Article
Department of Medicinal Chemistry, Faculty of Pharmacy – International Campus, Iran University of Medical Sciences, Tehran, Iran
Department of Toxicology (Pharmacy), Shahreza Branch Islamic Azad University, Isfahan, Iran
Department of Clinical Biochemistry, Kermanshah University of Medical Sciences, Kermanshah, Iran
January 2, 2016
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