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Eupartoium makinoi suppresses lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression

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Inflammation is involved in numerous diseases including cancer. Inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) play important roles in the development of certain inflammatory diseases. Eupatorium makinoi, which belongs to a family of Asteraceae plants, is used medicinally in East Asia. We investigated the effects of an ethanol extract of E. makinoi (EEM) on nuclear factor-kappa B (NF-κB) activation and the expression of iNOS and COX-2 with lipopolysaccharide (TLR4 agonist) in murine macrophages. EEM suppressed NF-κB activation and iNOS and COX-2 expression induced by LPS. These results suggest that EEM may regulate TLR4 signalling pathways and this may be a useful strategy for anti-inflammatory therapies.
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Keywords: Eupatorium makinoi; cyclooxygenase-2; inducible nitric oxide synthase; lipopolysaccharide; nuclear factor-κB

Document Type: Research Article

Affiliations: 1: Departments of Medical Science, College of Medical Sciences, SoonChunHyang University, Chungnam, Asan 336-745, Republic of Korea 2: Department of Biomedical Laboratory Science, College of Medical Sciences, SoonChunHyang University, Chungnam, Asan, 336-745, Republic of Korea 3: Department of Food Science and Nutrition, Hallym University, Chuncheon, Gangwon, 200-702, Republic of Korea 4: Department of Biological Environment, Kangwon National University, Chuncheon, Gangwon-do, 200-701, Korea

Publication date: July 4, 2015

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