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Immune modulation effects of soya bean fermentation food evaluated by an animal model

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A murine model was used to evaluate the role of soya bean fermentation broth (SFB) in immune-modulating a T helper type 1 (Th1)/T helper type 1 (Th2) response. The SFB feeding groups (0.1% and 0.4%) had significantly increased T-cell proliferation (47.4 ± 2.5% and 48.2 ± 5.6%, respectively) in the third week compared with the control group (43.3 ± 2.5%), and also significantly enhanced natural killer (NK) cell activity (33.2 ± 4.2% and 35.1 ± 5.9%, respectively) compared with the control group (24.8 ± 4.8%). The IL-2 concentrations of sera were 236.3 ± 4.3 and 251.3 ± 35.4 pg/106 cells in the SFB feeding groups respectively, which were almost double higher than the control group 144.1 ± 23.1 pg/106 cells. Conversely, the IL-4 concentration in sera was significantly decreased when stimulated by the mitogen concanavalin A (2 μg/ml) in SFB feeding group. The ratio of IL-2 to IL-4 in the SFB groups was 10.4 and 17.6, respectively, which was higher than that in the control group (4.7). The SFB is proposed to have the potential to induce T-cell proliferation and enhance the function of Th1 cells, then increased the secretion of IL-2, which enhanced NK cell activity. We suggest that the SFB might be a good resource for modulating immunity in human health care.
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Keywords: IL-2/IL-4; NK cell activity; Th1/Th2 cells; animal model; soya bean fermentation broth

Document Type: Research Article

Affiliations: 1: Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan 2: Department of Nephrology, Cathay General Hospital, Taipei, Taiwan 3: Department of Dentistry, Cheng-Hsin General Hospital, Taipei, Taiwan 4: School of Medicine, College of Medicine, Fu-Jen Catholic University, Taipei, Taiwan

Publication date: July 4, 2015

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