Immunomodulatory and radioprotective properties of Haberlea rhodopensis extract (HRE) in relation to the primary and secondary specific antibody production were evaluated in New Zealand white rabbits. Rabbits were immunised with keyhole limpet hemocyanin (KLH) and were treated
with HRE before irradiation with single dose of 2Gy. Control group without irradiation were also treated with HRE. Rabbits were reimmunised and treated again with HRE on Day 36. KLH-specific total IgM, G, A and KLH-specific IgG antibody production were determined during primary and secondary
antibody response by enzyme-linked immunosorbent assay (ELISA). We observed a well-defined γ-radiation-induced immunosuppression on the total primary antibody production. Application of HRE restored primary total KLH-specific antibody as well as significantly increased primary
KLH-specific IgG antibody response. We also established that HRE strongly enhanced KLH-specific antibody production after reimmunisation. We concluded that HRE exhibits immunostimulatory properties and could play protective role against γ-irradiation damage of immune response.
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Document Type: Research Article
Department of Molecular Biology, Immunology and Genetics, Faculty of Medicine, Trakia University, Stara Zagora, Bulgaria
Department of Genetics, Animal Breeding and Reproduction, Faculty of Agriculture, Trakia University, Stara Zagora, Bulgaria
May 4, 2015
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