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Heterogeneous IgG interacts with FcRn and its transport across gastrointestinal barrier

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The transport of heterogeneous IgG to Fc receptor-expressing leukocytes and serum was investigated by the complement fixation test in mice. The results showed that heterogeneous IgG could be transported into the blood by neonatal Fc receptor (FcRn) on the gut mucosal surface. The interactions between human FcRn and IgG of different animal species were determined. It showed that rabbit IgG had the highest affinity (KD) to human FcRn, and the following species were listed as: human, sheep, horse and cattle. These results indicated the functions of heterogeneous IgG depended on the transport through FcRn, which might protect IgG from being diluted or degraded.
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Keywords: FcR; FcRn–IgG interaction; IgG transport; complement fixation test; heterogeneous IgG; immune milk

Document Type: Research Article

Affiliations: Tianjin Key Laboratory of Food Biotechnology, Department of Bioengineering, Tianjin University of Commerce, Tianjin, People's Republic of China

Publication date: May 4, 2015

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