Spirulina platensis (SP) is well recognised for its abundant unsaturated fatty acids, especially γ-linolenic acid (GLA). In this study, GLA was extracted from SP. Antineoplastic and antithrombotic activities of GLA were evaluated by measuring the concentrations of reactive
oxygen species (ROS) and malondialdehyde, as well as inducing apoptosis in HepG2 human hepatoma cells and diphosphatase-induced platelet aggregation inhibition assay, respectively. The study suggests that the GLA extraction from SP using ethanol achieved a higher extraction yield of 8.3 g
kg−1 ± 0.17 g kg−1 (GLA/dry biomass) and inhibited cell proliferation in a dose- and time-dependent manner. GLA extract (250 µM) strongly induced ROS generation and lipid peroxidation as well as apoptosis. The extract also caused a concentration-dependent
antithrombotic effect on platelet aggregation in vitro. Thus, the GLA extract from SP can be applied in health care and functional foods.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
Document Type: Research Article
Beijing Key Laboratory of Forestry Food Processing and Safety, College of Biological Sciences and Biotechnology, Beijing Forestry University, Beijing, P.R., China
Beijing Engineering Research Center of Functional Peptides, China National Research Institute of Food & Fermentation Industries, Beijing, P.R., China
January 2, 2015
More about this publication?