Skip to main content
padlock icon - secure page this page is secure

Immunoregulatory role of Pleurotus eryngii superfine powder through intercellular communication of cytokines

Buy Article:

$63.00 + tax (Refund Policy)

Pleurotus eryngii, also known as thistle mushroom, is rich in proteins, dietary fibre and polysaccharides. It has been developed as a functional food due to its antioxidant, anti-fatigue, anti-viral and anti-tumour functions. The objective of this study was to investigate the mechanisms of the immunoregulatory and antioxidant effects of P. eryngii superfine powder (PESP) in vivo. Test mice were fed with a diet containing 6.67% PESP to explore its effect on mouse delayed-type hypersensitivity, phagocytic index, serum hemolysin, serum and liver glutathione peroxidase (GSH-PX) activities, serum superoxide dismutase (SOD) activity and malondialdehyde (MDA) content in liver homogenate. For the human study, volunteers received PESP at doses of 5, 10 or 15 g. Serum levels of 39 cytokines were determined before and after ingestion using a Millipore Human Kit and a liquid chip scanner. Our results showed that, in mice, dietary P. eryngii supplementation significantly increased the weight difference of ears (P < 0.01), phagocytic index (P < 0.05), serum hemolysin (P < 0.01), serum and liver GSH-PX activities (P < 0.01) and serum SOD activity (P < 0.01), but decreased MDA content (P < 0.01) in liver homogenate. In human trials, 5 g of PESP significantly decreased serum epidermal growth factor, while 15 g of PESP significantly decreased serum granulocyte–macrophage colony stimulating factor, macrophage-derived chemokine and tumour necrosis factor-α. No change was detected in serum cytokines after the administration of 10 g of PESP. P. eryngii can regulate innate and acquired immune functions in mice to execute antioxidant and anti-aging functions, and can alter human serum cytokines. The dual immunoregulatory effects of P. eryngii are consistent with the theory of traditional Chinese medicine.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics

Keywords: Pleurotus eryngii; cell–cell communication network; cytokine; immunoregulatory

Document Type: Research Article

Affiliations: 1: College of Food Science and Technology, Nanjing Agricultural University, Nanjing, China 2: Beijing Food Research Institute, Beijing, China 3: College of Food Science and Engineering, Nanjing University of Finance & Economics, Nanjing, China 4: College of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, China

Publication date: October 2, 2014

More about this publication?
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more