Studies on the association of BF1/BF2 gene expression patterns with traits of genetic resistance to Marek's disease in chickens
The aim was try to clarify the association of BF1 and BF2 gene expression patterns with the traits of genetic resistance to Marek's disease (MD) in chickens. An MD-resistant line and a common line of Xiayan chickens were used in the experiment. The productions of mRNA of BF1 and BF2 and Marek's disease virus (MDV) gene, meq, were quantified by quantitative real-time PCR on different days post-infection (dpi) with virulent MDV in the peripheral blood leukocytes (PBLs). Results indicated that the MDV loads were lower in the MD-resistant line compared to the common line. The mRNA levels of BF1 were significantly lower and levels of BF2 higher in the MD-resistant line whereas levels of BF1 were significantly higher and levels of BF2 lower in the common line. The results demonstrated that the expression modes of BF1 and BF2 genes might be related to traits of genetic resistance to MD in the chicken.
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Document Type: Research Article
Affiliations: 1: School of Life Science, Hunan University of Science and Technology, Xiangtan, China 2: Poultry Science and Health, Guangxi University, Nanning, China
Publication date: April 3, 2014