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Antioxidant and immunomodulatory effects of a α-glucan from fruit body of maitake (Grifola frondosa)

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The antioxidant and immunomodulatory effect of an α-glucan (designated here as MT-α-glucan) from fruit body of Maitake mushroom (Grifola frondosa) on D-galactose (D-gal)-induced senescent mice model was evaluated. Results showed that MT-α-glucan could ameliorate age-related alternations in both motor and memory activities of senescent mice. Treatment with MT-α-glucan (450 or 150 mg kg−1) significantly increased the body weight, hepatic superoxide dismutase and glutathione peroxidase activity, reduced glutathione content, the proliferative response and interleukine-2 (IL-2) production of splenocytes induced by ConA. Treatment with MT-α-glucan significantly decreased hepatic malondialdehyde content, the levels of macrophage proliferative response and IL-1 and NO production. These data suggest that MT-α-glucan has antioxidative and immunomodulatory effects on D-gal-induced senescent mice.
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Keywords: D-galactose; MT-α-glucan; ageing; antioxidation; immunomodulation

Document Type: Research Article

Affiliations: 1: School of Biology and Food Engineering, Hefei University of Technology, Hefei, 230009, China 2: Shandong University Medical College, Shandong Medical Imaging Research Institute, Jinan, 250021, China

Publication date: December 1, 2013

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