This study examined the phytochemical profile and the effects of Pleurotus fruiting bodies powder on cell-mediated immune response in both in vivo and in vitro assays. Although carbohydrates (55%, w/w) appear to be the most important immunomodulatory compound, secondary
metabolites (terpenoids, phenols and flavonoids) would also enhance immunity. Pleurotus powder was administered orally during 7 days to Balb/c mice (1000 mg/kg) and cyclophosphamide (CY; 100 mg/kg) was inoculated intraperitoneally at the beginning of the experiment. The delayed-type
hypersensitivity reaction measured at 48 and 72 h after antigen challenge was similar to that of control mice and it was associated with an increase in the mass index of popliteal lymph nodes (p< 0.05). An in vitro lymphoproliferative-stimulating response was also demonstrated
with aqueous and ethanolic extracts obtained from Pleurotus powder. These effects suggest that Pleurotus supplement could potentiate the cellular immune response and should be promising for further immunotherapy studies.
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Affiliations:1: Centre of Studies for Industrial Biotechnology (CEBI), Universidad de Oriente, Reparto Jiménez, Santiago de Cuba 5, CP, 90 500, Cuba 2: IRD-Biotrans Unit, IMEP Case 441, Faculty of Science of Saint Jérôme, University Paul Cézanne, Av. Escadrille, Normandie-Niemen, 13397 Marseille Cedex 20, France