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Agaricus brasiliensis mycelium supplementation in Sarcoma 180tumour-bearing mice reverses the immune response induced by the tumour

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The biological properties of Agaricus brasiliensis mycelium, including their immuno-stimulating and anti-tumour activities, have previously been investigated. The aim of this study was to evaluate the effects of long-term intake of A. brasiliensis mycelium cultivated on wheat grains by solid-state culture on tumour growth and immune response in Sarcoma 180 tumour-bearing mice. Mice received dietary supplementation with 100% or 50% Agaricus mycelium cultivated on wheat grains for 14 weeks and were inoculated with Sarcoma 180 tumours. We found that A. brasiliensis had anti-tumour activity, and that dietary supplementation with a 50% concentration (A50S) prevented loss of body weight, inhibited tumour growth, induced the increase of CD4+ T cells and CD25+ CD4+ T subsets in peripheral organs and downregulated Tumor necrosis factor alpha production in plasma. Our results confirm that dietary supplementation with Agaricus may offer immuno-modulatory activity and protection against tumour growth.
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Keywords: Agaricus brasiliensis; anti-cancer activity; edible mushroom; mice

Document Type: Research Article

Affiliations: 1: Department of Food Engineering,Midwest State University (UNICENTRO), Simeão de Camargo Varela de Sá, 03CEP 85040-080,Guarapuava,Paraná, Brazil 2: Division of Bioprocess Engineering and Biotechnology,Federal University of Paraná (UFPR), Jardim das AméricasCEP 81531-990,Curitiba,Paraná, Brazil 3: Department of Cellular Biology,Federal University of Paraná (UFPR), Jardim das AméricasCEP 81531-990,Curitiba,Paraná, Brazil 4: Laboratory of Agricultural and Livestock Technology,Pontifical Catholic University of Paraná, 16 BR 376 Km 14, CEP 83010-500,São José dos Pinhais,Paraná, Brazil 5: Department of Clinical Medical,Federal University of Paraná (UFPR), Jardim das AméricasCEP 81531-990,Curitiba,Paraná, Brazil 6: Brazilian Agricultural Research Corporation,Embrapa Dairy Cattle, Rua Eugênio do Nascimento, 610, Bairro Dom Bosco36038-330,Juiz de Fora,MG, Brazil 7: Faculty of Pharmacy, Pos Graduation Program in Pharmaceutic Science,Federal University of Pará (UFPA), Augusto Correa, S/NCEP 66095-110,Belém,Pará, Brazil 8: Department of Phisiology,Federal University of Paraná (UFPR), Jardim das AméricasCEP 81531-990,Curitiba,Paraná, Brazil

Publication date: June 1, 2013

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