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Studies of the protective effect and antioxidant mechanism of blueberry anthocyanins in a CC14-induced liver injury model in mice

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This study investigated the protective effects and antioxidant mechanisms of blueberry anthocyanin extract (BBAE) in vivo and in vitro using the model of acute CC14-induced liver injury in mice. It was found that BBAE significantly inhibited CC14-induced liver injury and inhibited acute ethanol-induced increases in alanine aminotransferase, aspartate aminotransferase and malondialdehyde in a dose-dependent manner (P<0.05). The activities of superoxide dismutase, catalase and glycogen and glutathione reductase were markedly increased in the anthocyanin group (P<0.01). BBAE also significantly suppressed cellular injury and apoptotic cell death. In summary, BBAE possesses marked protective effects against CC14-induced liver injury, related to its ability to reduce human embryonic-liver cell (L-02) apoptosis and damage induced by oxidative stress. These findings indicate that BBAE may be of value in protecting against acute liver injury, providing pharmacological evidence supporting its clinical application.
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Keywords: CC14-induced liver injury; antioxidant activity; blueberry anthocyanidin; human embryonic-liver cell (L-02); oxidation-response

Document Type: Research Article

Affiliations: Department of Food Science, College of Biological Sciences and Biotechnology,Beijing Forestry University, Qinghua East Road 35 in Haidian District100083,Beijing, China

Publication date: December 1, 2012

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