Anti-inflammatory activity of Agaricus blazei in different basidiocarp maturation phases
Agaricus blazei Murrill ss. Heinemann (Agaricus brasiliensis Wasser et al.; Agaricus subrufescens Peck) has raised interest in the scientific community due to its therapeutic properties. Although there are numerous studies about this fungus a few of them
study the anti-inflammatory activity and the relationship with basidiocarp development phases. Thus, the objective of this study was to evaluate the effect of A. blazei extracts of closed and opened basidiocarp on the cell migration of rats submitted to an inflammatory challenge. The
basidiocarp extracts were administered by gavage at 55 or 110 mg/kg. The inflammatory challenge was performed by administering phlogistic agent (carrageenan 2%) in an air-pouch induced in the animal subcutaneous tissue. It was concluded that the extracts affect leukocyte mobilisation regulation;
closed basidiocarp extract in doses of 55 and 110 mg/kg and opened basidiocarp extract in 110 mg/kg modulate the anti-inflammatory response.
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Document Type: Research Article
Universidade Paranaense – Campus I, Laboratório de Biologia Molecular, Programa de Mestrado em Biotecnologia Aplicada à Agricultura, Praça Mascarenhas de Moraes, 4282, CP 224, CEP 87.502-050UmuaramaPR,
Curso de Farmácia, Praça Mascarenhas de Moraes, 4282, CEP 87.502-050UmuaramaPR, Brazil
Universidade Paranaense – Campus I, Laboratório de Biologia Molecular, Programa de Mestrado em Biotecnologia Aplicada à Agricultura, Praça Mascarenhas de Moraes, 4282, CP 224, CEP 87.502-050UmuaramaPR, Brazil
December 1, 2011
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