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Effect of Pleurotus djamor var. roseus, an edible mushroom on neutrophil functions

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Immune stimulation is an effective as well as protective approach against emerging infectious diseases. Mushroom has been valued throughout the world as both food and medicine for thousands of years. The immunomodulatory activities of methanolic extract of Pleurotus djamor var. roseus (MEPDR, 500 mg/kg/body weight for 48 days) were assessed by testing the various neutrophil functions like adherence, phagocytosis (phagocytic index), avidity index and nitroblue tetrazolium reduction in albino rats. Rats were randomly divided into four groups namely, MEPDR treated and corresponding immunised rats were used. Sheep red blood cells (SRBCs) were used for immunisation. The immunised rats were inoculated with SRBCs. The studied neutrophil functions were significantly stimulated in MEPDR-treated groups.
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Keywords: immunology; mushroom; neutrophil

Document Type: Research Article

Affiliations: 1: Centre for Advance Studies in Botany,University of Madras, Guindy CampusChennai600025Tamil Nadu, India 2: Department of Biotechnology,Kumaraguru College of Technology, Coimbatore641006Tamil Nadu, India 3: Department of Microbiology,Bharathidasan University College for Women, Orathanadu614625ThanjavurTamil Nadu, India 4: Department of Microbiology,Sathyabama University Dental College & Hospital, Jeppiaar Nagar, Old Mahabalipuram RoadChennai600119Tamil Nadu, India

Publication date: September 1, 2011

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