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Expression of the human -defensin-1 induced by dehydroandrographolide in human pulmonary gland epithelial cells

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In this study we observed the enhanced mRNA and protein expression of human -defensin-1 (hBD-1) induced by dehydroandrographolide (DA) in human gland epithelial cells and explored the mechanism of DA on infection treatment. Human pulmonary gland epithelial cells were incubated with DA, then were harvested for hBD-1 expression detection. The mRNA expression of hBD-1 was detected by RT-PCR while the protein expression was detected by Western blot. It was found that DA can up-regulate mRNA and protein expression of hBD-1, the optimal concentration was 80 ยตM, the maximal expression of hBD-1 mRNA and protein occurred after 8 h. The DA can up-regulate mRNA and protein expression of hBD-1 in human gland epithelial cells. It suggests that -defensin-1 may play an important role in the treatment of infective diseases with DA.
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Keywords: dehydroandrographolide; human pulmonary gland epithelial cells; human ๎œ-defensin-1

Document Type: Research Article

Affiliations: 1: Department of Pharmacology, West China Medical Center, Preclinical and Forensic Medical College, Sichuan University, Chengdu, China 2: Sichuan Academy of Chinese Medicine Sciences, Chengdu, China 3: The Joint Research Center of West China Second University Hospital, Sichuan University and Faculty of Medicine, University of Hong Kong, Chengdu, China

Publication date: December 1, 2010

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