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Conjugated linoleic acids alleviated immunosuppression in broiler chickens exposed to cyclosporin A

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An experiment with 3×2 factorial arrangement was carried out to determine the effects of dietary conjugated linoleic acids (CLA) on immune function in cyclosporin A (CsA)-immunosuppressed chickens. Two hundred and sixteen one-day-old chickens were randomly allocated into six treatments with CLA (80:20 of c9, t11-CLA:t10, c12-CLA) levels (0, 1.0% and 2.0%) and immunosuppression (treated with CsA or saline with olive oil). CsA treatment significantly (P<0.05) decreased peripheral blood lymphocyte proliferation in response to concanavalin A (Con A) mitogen, CD4+ lymphocyte subsets and Interleukin-2 (IL-2) production. CLA diets significantly (P<0.05) increased the relative weight of the bursa, lymphocyte proliferation in response to Con A, IL-2 production and CD4+ lymphocyte subsets. Interaction between CLA and CsA on lymphocyte proliferation in response to Con A and CD4+ lymphocyte subsets was observed, which indicated that c9, t11-CLA may play a primary role in enhancing immune function under both normal physiological and immunosuppressive conditions.
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Keywords: Interleukin-2; conjugated linoleic acids; immunosuppression; lymphocyte proliferation; lymphocyte subsets

Document Type: Research Article

Affiliations: The State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, P.R. China

Publication date: December 1, 2010

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