Skip to main content
padlock icon - secure page this page is secure

Anti-inflammatory effects of lansai C and D cause inhibition of STAT-1 and NF-B activations in LPS-induced RAW 264.7 cells

Buy Article:

$63.00 + tax (Refund Policy)

In inflammation, proinflammatory cytokines induce the formation of large amounts of nitric oxide (NO) by inducible nitric oxide synthase (iNOS), and compounds that inhibit NO production have anti-inflammatory effects. In the present study, we investigated the effects of lansai C and D on NO production in lipopolysaccharide-induced RAW 264.7 cells, and evaluated the mechanisms of action of the compounds. Lansai C and D inhibited iNOS protein and mRNA expression and also NO production in a dose-dependent manner. These compounds inhibited the activation of nuclear factor-B, which is a significant transcription factor for iNOS and also inhibited the activation of the signal transducer and activator of transcription-1, another important transcription factor for iNOS. The present study characterises the effects and mechanisms of lansais on iNOS expression and NO production in activated macrophages. The results explain the pharmacological efficacy of lansais as anti-inflammatory compounds.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics

Keywords: NF-B; RAW 264.7 cells; STAT-1; anti-inflammatory activity; lansai C and D

Document Type: Research Article

Affiliations: 1: Department of Microbiology, Faculty of Science, Silpakorn University, Nakorn Pathom, Thailand 2: Department of Chemistry, Faculty of Science, Silpakorn University, Nakorn Pathom, Thailand 3: Kunming Institute of Botany (KIB), The Chinese Academy of Sciences, Kunming, China

Publication date: March 1, 2010

More about this publication?
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more