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Carvacrol has the priming effects of reactive oxygen species (ROS) production in C6 glioma cells

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Carvacrol (5-isopropyl-2-methylphenol) is the major component of Plectranthus amboinicus. Several studies have shown that carvacrol has antibacterial, antifungal and insecticidal effects, but the mechanisms that govern these processes are unclear. Reactive oxygen species (ROS) play a major role in host defence eradication of microorganisms. In this study, we provide evidence that carvacrol has priming effects on ROS production in C6 glioma cells. By viability assay, carvacrol was not cytotoxic to C6 cells at levels below 300 ┬ÁM. We pretreated C6 cells with or without carvacrol and stimulated them with LPS/TPA, after which the C6 cells produced more ROS in TPA/LPS with carvacrol than in LPS/TPA alone. Thus, carvacrol has priming effects on ROS production during stimulation by bacterial cell wall components. Our research provides a possible mechanism that underlies the antimicrobial effects of carvacrol.
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Keywords: C6 glioma cells; LPS/TPA; carvacrol; enhance; priming; reactive oxygen species

Document Type: Research Article

Affiliations: 1: Department of Food Science, National PingTung University of Science and Technology, PingTung, Taiwan,Graduate Institute of Biotechnology, National PingTung University of Science and Technology, Pingtung, Taiwan 2: Department of Food Science, National PingTung University of Science and Technology, PingTung, Taiwan 3: Graduate Institute of Animal Vaccine Technology, National PingTung University of Science and Technology, Pingtung, Taiwan

Publication date: March 1, 2010

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