Skip to main content
padlock icon - secure page this page is secure

Effects of chitosan pentamer and chitosan hexamer in vivo and in vitro on gene expression and secretion of cytokines

Buy Article:

$63.00 + tax (Refund Policy)

Effects of chitosan pentamer ((GLcN)5) and chitosan hexamer ((GLcN)6) in vivo and in vitro on gene transcription and protein translation of interleukin-1 (IL-1), tumour necrosis, factor alpha (TNF-α), interleukin-2 and interferon- (IFN-) were investigated by relatively quantitative reverse transcription-polymerase chain reaction and enzyme-linked immunosorbent assay. The results showed that the expression of IL-1 mRNA, TNF-α mRNA, IFN- mRNA as well as the secretion of IL-1, TNF-α and IFN- can both be promoted by (GLcN)6 and (GLcN)5. The promotion effects caused by (GLcN)6 were greater than that of (GLcN)5. Gene transcription and protein secretion of cytokines were promoted by (GLcN)5 and (GLcN)6 in vivo and in vitro and thus the immuno-modulating ability was promoted. This may be one of the molecular mechanisms for elucidation of immunity of chitooligosaccharides.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics

Keywords: chitosan hexamer; chitosan pentamer; cytokines; gene expression; secretion

Document Type: Research Article

Affiliations: 1: College of Life and Environment Science, Shanghai Normal University, Shanghai, P.R. China 2: School of Basic Medical Science, Nantong University, Nantong, P.R. China 3: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, P.R. China

Publication date: September 1, 2009

More about this publication?
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more