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Anti-allergic effect of Petasites japonicus fermented with lactic acid bacteria in mice

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Petasites japonicus (PJ, family Asteraceae) was fermented with lactic acid bacteria (LAB), Bifidobacterium breve (BB) or Lactobacillus acidophilus (LA), and its allergic effect was investigated. LAB-fermented PJs more potently inhibited IgE-antigen-stimulated degranulation of RBL-2H3 cells than non-fermented PJ, with BB-fermented PJ more potent than LA-fermented PJ. Fermented PJ more potently inhibited TNF-α and IL-4 cytokine expression and transcription factor NF-B activation in IgE-induced RBL-2H3 cells. PJ and BB-fermented PJ also inhibited IgE-antigen-induced passive cutaneous anaphylaxis (PCA) reactions as well as compound 48/80-induced scratching behaviours in mice, with fermented PJ more potent than non-fermented PJ. These findings suggest that PJ may show anti-allergic effects by inhibiting degranulation, and TNF-α and IL-4 expression and its anti-allergic effects can be enhanced by LAB fermentation.
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Keywords: Petasites japonicus; fermentation; itching; lactic acid bacteria; passive cutaneous anaphylaxis reaction

Document Type: Research Article

Affiliations: 1: College of Pharmacy, Kyung Hee University, Dongdaemun-ku, Seoul, Republic of Korea 2: Rural Development Administration, Suwon-shi, Gyunggi-do, Republic of Korea

Publication date: June 1, 2009

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