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Anti-inflammatory activity of lansais from endophytic Streptomyces sp. SUC1 in LPS-induced RAW 264.7 cells

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This research was undertaken to find the in vitro inflammatory action of lansai A-D produced by Streptomyces sp. SUC1. We investigated the effects of lansai C not only on the formation of nitric oxide (NO), prostaglandin E2 (PGE2), tumour necrosis factor (TNF-α), interleukin (IL)-1α, IL-6 and IL-10, but also on inducible NO synthase and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells. The data obtained were consistent with the modulation of inducible nitric oxide synthase enzyme expression. A similar fashion was also observed when LPS-induced PGE2 release and COX-2 expression were tested. The significant inhibitory effects were shown in concentration-dependent manners. In addition, lansai C also mildly but significantly reduced the formation of TNF-α. These findings support the application of lansai C as anti-inflammatory agent.
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Keywords: RAW 264.7 cells; anti-inflammatory activity; endophytic Streptomyces; lansai C

Document Type: Research Article

Affiliations: 1: Department of Microbiology, Silpakorn University, Nakorn Pathom, Thailand 2: Department of Chemistry, Silpakorn University, Nakorn Pathom, Thailand 3: Kunming Institute of Botany (KIB), The Chinese Academy of Sciences, Kunming, China

Publication date: March 1, 2009

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